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Objective To study the prevalence of diabetic nephropathy (DN) and the relationship between dietary pattern and risk. Methods From August 2018 to May 2021, 655 T2DM patients in Wuhan Puren Hospital, including 338 males and 317 females, were divided into T2DM group (n=368 cases) and DN group (n=287 cases) according to whether patients had DN. The uniformly trained staff of our hospital used the simplified version of food intake frequency questionnaire designed for diabetes to investigate the reasonable dietary intake of patients in nearly one year. Clinical data of patients in the two groups were collected and the intake of protein, fat, carbohydrate and dietary fiber in the two groups was statistically analyzed. Logistics regression was used to analyze the formula independent risk factors of DN in T2DM, and Pearson correlation analysis was performed on the incidence of diabetic nephropathy and dietary pattern. Results Among of 655 T2DM patients, there were 287 (43.82%) patients with DN, including 149 males and 138 females. The average age, duration of diabetes, smoking in DN group were significantly higher than those in T2DM group (P0.05). Energy, protein intake, carbohydrate and fat intake in DN group were significantly higher than those in T2DM group (P<0.05). Multivariate logistic regression analysis showed that protein, carbohydrate and fat intake were independent risk factors for DEVELOPING DN in T2DM patients (P<0.05). According to Pearson correlation analysis, the risk of developing DN in T2DM patients was positively correlated with protein and fat intake (r=0.449 , 0.517, P<0.05). Conclusion PATIENTS with T2DM have a higher risk of DEVELOPING DN, which is closely related to dietary intake. Reasonable allocation of dietary intake can reduce the risk of developing DN.
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Objective To explore the association of MTHFR C677T polymorphism and birth body mass with the vulnerability of autism in Chinese Han population. Methods Totally 1 505 children with au-tism have been recruited,using the diagnosis and statistical manual,4th revised version ( DSM-IV-R) diag-nostic criteria for autism. And 1 308 healthy control subjects sex matched with the children with autism were enrolled for the study. All the participants were identified the birth body mass ( kg) according to the birth medical recording. All the subjects were examined the MTHFR C677T genotypes,using the polymerase chain reaction- restrict fragment length polymorphism (PCR-RFLP) methods. The frequencies of genotypes,alleles and birth body mass were compared between autism and healthy control groups using the chi-square and other tests. Results The MTHFR C677T (P=0. 004,OR=1. 18,95% CI=1. 02-1. 29),low birth body mass (<2. 5 kg) (P=0. 001,OR=1. 04,95%CI=1. 02-1. 06),and their interactive effects ( P=0. 0001,OR=2. 18,95%CI=1. 44-3. 32) were associated with the vulnerability of autism. Conclusions The MTHFR C677T polymorphism,low birth body mass and their interactive effects might be associated with susceptibility of autism in Chinese Han population.
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Objective @#To evaluate the risk of cardiovascular disease in hypertensive patients managed by communities in Tongxiang in the next 10 years,and to provide evidence for the development of cardiovascular disease prevention strategies. @*Methods@#The information about hypertensive patients managed by communities was collected from Tongxiang resident health records management system. The risk of ischemic cardiovascular disease（ICVD）in the next 10 years was assessed by the Assessment Scale of 10-Year ICVD Risk in Chinese.@*Results@# A total of 27 173 hypertensive patients managed by communities with complete data were recruited,including 11 868 males,accounting for 43.68%,and 15 305 females,accounting for 56.32%. The median（inter-quartile range）of the total scores of 10-year ICVD risk in hypertensive patients was 8.00（3.00）,with 9.00（2.00）in males and 8.00（2.00）in females. The total scores of 10-year ICVD risk in males was significantly higher than those in females（P<0.05）. A total of 8 764 patients had high 10-year ICVD risk,accounting for 32.25%. The proportion of high10-year ICVD risk in females with hypertension was higher than that in males（P<0.05）. The weights of ICVD risk factors in males were 54.58% in age,17.42% in systolic blood pressure,14.27% in smoking,7.77% in body mass index,4.51% in total cholesterol and 1.45% in diabetes;the ones in females were 63.57% in age,14.63% in systolic blood pressure,9.81% in body mass index,6.00% in total cholesterol,5.88% in diabetes and 0.11% in smoking.@*Conclusion @#The ICVD risk of hypertensive patients managed by communities in Tongxiang is higher in the next 10 years. Male patients should focus on the control of blood pressure and smoking,while female patients should focus on the control of blood pressure and body weight.
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Introducción: El diagnóstico de fascitis necrosante es muy difícil y precisa un alto grado de sospecha clínica. Debido a la complejidad para diagnosticar esta entidad, en 2004, Wong propone un algoritmo diagnóstico basado en parámetros de laboratorio (escala LRINEC: Laboratory Risk Indicator for Necrotizing Fascitis). Objetivo: Demostrar la utilidad diagnóstica de la escala LRINEC en la fascitis necrosante. Material y Método: Se diseña un estudio prospectivo y descriptivo, tipo serie de casos, en 28 pacientes atendidos en el Servicio de Ortopedia y Traumatología del Hospital General Docente Julio Arístegui Villamil con el diagnóstico de fascitis necrosante, en el período comprendido entre enero de 2000 y junio de 2015. Se calcula el índice LRINEC (Laboratory Risk Indicator for Necrotizing Fascitis), para predecir el riesgo de la enfermedad. Resultado: El índice LRINEC mostró una estratificación de riesgo intermedio (6-7). En los pacientes que sobrevivieron se encontraron menores valores de Proteína C reactiva que los fallecidos (t=9,7). Los pacientes del estudio que fallecieron presentaron niveles de hemoglobina menores que los supervivientes (t=8,5) y valores de creatinina mayores (t=5,5). La media del recuento de leucocitos en ambos grupos se encontró por debajo de 15x109 cels/µl. El área bajo la curva ROC fue de 0,607 (IC95 por ciento=0,47-0,73) para el Score LRINEC de este estudio. El punto de corte tuvo una sensibilidad de 66 por ciento y una especificidad de 75 por ciento. Conclusiones: La escala LRINEC es una herramienta útil cuando se sospecha una fascitis necrosante, pero se suele requerir información adicional para confirmar el diagnóstico(AU)
Introduction: The diagnosis of necrotizing fasciitis is very difficult to make, and requires a high degree of clinical suspicion. Because of the complexity of the diagnosis of this entity, Wong proposed an algorithm based on laboratory parameters in 2004 (LRINEC scale: Laboratory Risk Indicator for Necrotizing Fascitis). Objective: To demonstrate the diagnostic utility of LRINEC scale in necrotizing fasciitis. Material and Method: A descriptive prospective case series study was designed in 28 patients treated in the Department of Orthopedics and Traumatology of the General Teaching Hospital Julio Arístegui Villamil with the diagnosis of necrotizing fasciitis, from January 2000 to June 2015. LRINEC (Laboratory Risk Indicator for Necrotizing Fascitis) score is calculated to predict risk of the disease. Results:LRINEC score showed an intermediate risk stratification (6-7). In the patients that survived, lower C-reactive protein levels than the ones in the deceased patients were found (t=9,7). The patients who were included in the study and died presented lower levels of hemoglobin than the ones who survived (t=8,5), and higher values of creatinine (t=5,5). The average value of leukocytes recount in both groups was below 15x109 cels/µl. The area under the ROC curve was 0,607 (IC95 percent=0,47-0,73) for the LRINEC Score in this study. The cutoff point had a sensitivity of 66 percent and a specificity of 75 percent. Conclusions: LRINEC scale is a useful tool when a necrotizing fasciitis is suspected, but additional information is usually required to confirm the diagnosis(AU)
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Humans , Male , Female , Algorithms , Fasciitis, Necrotizing/diagnosis , Epidemiology, Descriptive , Prospective Studies , Indicators and Reagents/methodsABSTRACT
Objective: To clarify the meaning and definition method of low-income group, summarize the current economic risk of disease for rural low-income group and the risk pooling effect of medical insurance system. Methods: Using literature research method to systematically review the relevant studies of economic risk of disease for low-income group in rural areas. Results: The risk pooling effects of various medical insurance systems are different. Conclusion: On the basis of defining low-income group scientifically, it is necessary to promote the economic risk protection effect of medical security schemes for low-income group in rural area.